| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1929 | |
| Phytochemical name or plant extracts | Cis-khellactone | |
| PMID | 29682182 | |
| Literature evidence | Cis-khellactone concentration-dependently decreased cell viability by increasing the level of reactive oxygen species (ROS) and decreasing mitochondrial membrane potential (MMP), which are related to all three types of PCD. | |
| IUPAC name | 9,10-dihydroxy-8,8-dimethyl-9,10-dihydropyrano[2,3-f]chromen-2-one | |
| Phytochemicals’ class or type of plant extracts | Furochromone | |
| Source of phytochemicals or plant Extracts | Angelica amurensis | |
| Geographical availability | Amur, China South-Central, Inner Mongolia, Japan, Khabarovsk, Korea, Manchuria, Primorye, Sakhalin | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer, Colon cancer, Cervical cancer , Kidney cancer | |
| Target gene or protein | VDAC1, Bax, Bak | |
| Gene or Protein evidence | Mitochondrial fractionation data revealed that cis-khellactone induced the translocation of BAX and BAK into mitochondria as well as the overexpression of VDAC1, which probably accelerates MMP disruption and finally cell death. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | cis-khellactone acts as an anti-cancer drug by inhibiting cancer cell proliferation at low concentrations and inducing cell death at high concentrations with minimal toxicity to normal cells. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, BT-20, BT-549, T47D, SKBR-3, MDA-MB-453, HS578T, MDA-MB-468, HCT116, HT-29, HeLa, SiHa, HEK293T, HEK293 | |
| Additional information | Furthermore, Western blot analysis showed that cis-khellactone induced three types of programmed cell death (PCD): apoptosis, autophagy-mediated cell death, and necrosis/necroptosis. Cis-khellactone concentration-dependently decreased cell viability by increasing the level of reactive oxygen species (ROS) and decreasing mitochondrial membrane potential (MMP), which are related to all three types of PCD. | |
| PubChem ID | 253856 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:837554-1 | |
| Safety | Importantly, MCF10A cells appeared to be much less sensitive to cis-khellactone treatment than the MCF7 and MDA-MB-231 cancer cells, implying that normal cells are less affected by this compound |