| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-422 | |
| Phytochemical name or plant extracts | Cinnamic Acid | |
| PMID | 32767960 | |
| Literature evidence | CONCLUSION: Thus, from the above observations, we can conclude that CA is an effective anticancer agent that can induce apoptosis in breast cancer cells via TNFA-TNFR1 mediated extrinsic apoptotic pathway. | |
| IUPAC name | (E)-3-phenylprop-2-enoic acid | |
| Phytochemicals’ class or type of plant extracts | Monocarboxylic acid | |
| Source of phytochemicals or plant Extracts | Goniothalamus laoticus | |
| Geographical availability | China South-Central, Laos, Thailand | |
| Plant parts | Flowers | |
| Other cancers | Breast cancer, Cervical cancer, Leukemia | |
| Target gene or protein | TNF-α, TNFR1 , Caspase 8, Caspase 3 | |
| Gene or Protein evidence | Additionally, immunoblotting showed the abundance of TNFA, TNF Receptor 1 (TNFR1) and cleaved caspase-8/-3 proapoptotic proteins to increase with CA treatment. Subsequently, blocking of TNFA-TNFR1 signalling by small molecule inhibitor, R-7050, reduced the expression of cleaved caspase-8 and caspase-3 at the protein level. | |
| Target pathways | TNFA-TNFR1 mediated extrinsic apoptotic pathway. | |
| IC50 | NA | |
| Potency | Thus, from the above observations, we can conclude that CA is an effective anticancer agent that can induce apoptosis in breast cancer cells via TNFA-TNFR1 mediated extrinsic apoptotic pathway. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, HeLa, K562 | |
| Additional information | Subsequently, trypan blue assay and comet assay showed CA to cause cell death and DNA damage, respectively, in the MDA-MB-231 cells. Using AO/EtBr staining and sub-G1 analysis, we further established CA to increase apoptosis. | |
| PubChem ID | 444539 | |
| Additional PMIDs | 23140579 27573001 27618000 8657175 31613725 19573585 24289290 29369483 15577215 17436587 25469660 15924924 23994083 29638061 16808933 18647433 33233182 18835421 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:73209-1 | |
| Safety | NA |