| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1875 | |
| Phytochemical name or plant extracts | Cinnamaldehyde | |
| PMID | 27245453 | |
| Literature evidence | Antibacterial activity was measured by Kirby-Bauer disc diffusion method while antiproliferative activity of test compounds was measured by sulforhodamine-B (SRB) assay. | |
| IUPAC name | (E)-3-phenylprop-2-enal | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Cinnamomum cassia | |
| Geographical availability | Bangladesh, Borneo, China South-Central, China Southeast, Hainan, Jawa, Lesser Sunda Is., Myanmar, Philippines, Sulawesi, Sumatera, Taiwan, Vietnam | |
| Plant parts | NA | |
| Other cancers | Lung cancer, Breast cancer, Colon cancer | |
| Target gene or protein | BRCA1, TOPO1, ERCC1 | |
| Gene or Protein evidence | In addition, cinnamaldehyde suppressed BRCA1, TOPO1, ERCC1 and TS mRNA expression, except for OPRT expression, which was markedly upregulated. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | cinnamaldehyde and eugenol displayed moderate antiproliferative activity against breast (T47D) and lung (NCI-H322) cancer cell lines (Fig. 6) showing anticancer potential which signifies their role in inhibiting cancer progression. | |
| Cell line/ mice model | HT-29, LoVo, T47D, NCI-H322 | |
| Additional information | Cinnamaldehyde possessed metal ion chelating, lipo-protective, antibacterial and antiproliferative activities | |
| PubChem ID | 637511 | |
| Additional PMIDs | 24276478 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:463328-1 | |
| Safety | NA |