| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-725 | |
| Phytochemical name or plant extracts | Cimicifoetiside B | |
| PMID | 17266751 | |
| Literature evidence | Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells. | |
| IUPAC name | [(2S,3R,4S,5S)-2-[[(1S,2R,3S,4R,7R,9S,12R,14S,17R,18R,19R,21R,22S)-22-(2-acetyloxypropan-2-yl)-2-hydroxy-3,8,8,17,19-pentamethyl-23,24-dioxaheptacyclo[19.2.1.01,18.03,17.04,14.07,12.012,14]tetracosan-9-yl]oxy]-4,5-dihydroxyoxan-3-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid glycoside | |
| Source of phytochemicals or plant Extracts | Cimicifuga foetida | |
| Geographical availability | British Columbia, Oregon, Washington | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 10.21 μM against MDA-MB-A231 | |
| Potency | Both compounds 1 and 2 exhibited potent cytotoxicity against rat EAC (Ehrlich ascites carcinoma) and MDA-MB-A231 (human breast cancer) cells with IC50 values of 0.52 and 6.74 microM for 1, and 0.19 and 10.21 microM for 2, suggesting their potential for further investigation as anti-cancer agents. | |
| Cell line/ mice model | MDA-MB-A231 | |
| Additional information | NA | |
| PubChem ID | 16019986 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:709432-1 | |
| Safety | NA |