| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-130 | |
| Phytochemical name or plant extracts | Cichorin D | |
| PMID | 32932909 | |
| Literature evidence | Moreover compounds 1-3 did not show any promising anthelmintic effects. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Naphthalane derivative | |
| Source of phytochemicals or plant Extracts | Cichorium intybus | |
| Geographical availability | Afghanistan, Albania, Algeria, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Cape Verde, Central European Rus, Corse, Cyprus, Czechoslovakia, Denmark, East Aegean Is., East European Russia, Egypt, Finland, France, Germany, Greece, Hungary, Iran, Iraq, Italy, Kazakhstan, Kirgizstan, Kriti, Krym, Lebanon-Syria, Morocco, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Pakistan, Palestine, Poland, Portugal, Romania, Sardegna, Sicilia, Sinai, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, West Himalaya, Yugoslavia | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Ewing's sarcoma, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | MTT assay IC50 = >100 µM against MDA-MB-468 CV assay IC50 = >100 µM against MDA-MB-468 MTT assay IC50 = >100 µM against MDA-MB-231 CV assay IC50 = >100 µM against MDA-MB-231 | |
| Potency | Whereas Cichorins D was not active (IC50s > 100 µM) in all tested cell lines, Cichorins E exhibited anti-proliferative effects in the triple-negative breast cancer (TNBC) cell line MDA-MB-468 (IC50 = 85.9 µM and 80.0 µM when determined by MTT and CV assay, respectively) and the Ewing’s sarcoma cell line SK-N-MC (IC50 = 71.1 µM and 56.4 µM using MTT and CV assay, respectively) | |
| Cell line/ mice model | MDA-MB-468, MDA-MB-231, SK-N-MC, PC-3 | |
| Additional information | Phytochemical investigations of C. intybus provided two new naphthalane derivatives viz., cichorins D (1) and E (2) along with one new Quinone, cichorin F (3). | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:194533-1 | |
| Safety | NA |