| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-431 | |
| Phytochemical name or plant extracts | Christia vespertilionis extract | |
| PMID | 34665399 | |
| Literature evidence | The selective extract was evaluated for its ability to induce apoptosis using Annexin V-FITC apoptosis staining and the expression of molecular genes using qualitative reverse transcription-polymerase chain reaction (RT-PCR) against MCF7 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Dichloromethane fraction (CV-Dcm) extract | |
| Source of phytochemicals or plant Extracts | Christia vespertilionis | |
| Geographical availability | Cambodia, China Southeast, Hainan, Jawa, Lesser Sunda Is., Malaya, Maluku, Thailand, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | PCNA, Bax, cyt-c, Caspase 8, Caspase 3, Bcl-2 | |
| Gene or Protein evidence | he CV-Dcm extract induced downregulation of PCNA level. The apoptotic genes were also triggered in both extrinsic and intrinsic signaling pathways, affecting a 1.5-fold increase in BAX, 1.4-fold increase in cytochrome c, 1.3-fold increase in caspase-8, 1.7-fold increase in caspase-3 and 0.5-fold-decrease in BCL-2. | |
| Target pathways | Extrinsic and intrinsic signaling pathways | |
| IC50 | 24 µg/mL against MCF-7 | |
| Potency | The present work strongly suggests that high efficacy of CV-Dcm extract was attributed to its antiproliferative and apoptosis-inducing activation in MCF7 cells, most likely due to its favourable compounds. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Christia vespertilionis, commonly known as 'Daun Rerama', has recently garnered attention from numerous sources in Malaysia as an alternative treatment. | |
| PubChem ID | NA | |
| Additional PMIDs | 32512700 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:486281-1 | |
| Safety | NA |