| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-780 | |
| Phytochemical name or plant extracts | Chlorogenic acid | |
| PMID | 30257424 | |
| Literature evidence | CGA is becoming very attractive due to its potential use as preventive and therapeutic agent in many diseases, including cancer. | |
| IUPAC name | (1S,3R,4R,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Pavetta indica | |
| Geographical availability | Andaman Is., Assam, Bangladesh, East Himalaya, India, Laccadive Is., Nicobar Is., Sri Lanka | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | The presence of caffeic acid or chlorogenic acid inhibited DNA methylation predominantly through a non-competitive mechanism, and this inhibition was largely due to the increased formation of S-adenosyl-L-homocysteine (SAH, a potent inhibitor of DNA methylation), resulting from the catechol-O-methyltransferase (COMT)-mediated O-methylation of these dietary catechols. | |
| IC50 | NA | |
| Potency | Overall, our results increase the evidence of CGA as a possible anticancer agent and illustrate the potential for clinical applications of sol-gel synthesized SiO₂/PEG/CGA materials. | |
| Cell line/ mice model | MDA-MB-435, MCF-7, MDA-MB-231, T-47D and BJ-hTERT | |
| Additional information | Chlorogenic acid scavenges free radicals, which inhibits DNA damage and may protect against the induction of carcinogenesis. In addition, this agent may upregulate the expression of genes involved in the activation of the immune system and enhances activation and proliferation of cytotoxic T-lymphocytes, macrophages, and natural killer cells. Chlorogenic acid also inhibits the activity of matrix metalloproteinases. | |
| PubChem ID | 1794427 | |
| Additional PMIDs | 35204168 19530711 16081510 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:759752-1 | |
| Safety | NA |