| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1924 | |
| Phytochemical name or plant extracts | Chlorella minutissimma extract | |
| PMID | 29633599 | |
| Literature evidence | The study aimed identification and analysis of inhibitory activity of microalgal components extracted from Chlorella minutissima against human MMPs. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Protein Extract | |
| Source of phytochemicals or plant Extracts | Chlorella minutissima | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP1, MMP2, MMP9, TIMP-3, c-Jun | |
| Gene or Protein evidence | The CP extract successfully inhibited MMP-1, -2, and -9 at different expression levels through TIMP-3 upregulation and c-Jun downregulation. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The results reveal that the treatment with CP extract decreased the mRNA expression of MMP-1, MMP-2, and MMP-9 by 0.26-, 0.29-, and 0.40-fold, respectively, at 20 μg/ml concentration as well as inhibited the activity of MMP-2 and MMP-9 by 37.56 and 42.64%, respectively, at 15 μg/ml concentration. Additionally, upregulated mRNA expression of tissue inhibitor of metalloproteinases-3 (TIMP-3) by 1.68-fold was seen in HepG2 cells at 20 μg/ml concentration treatment group. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | However, CP extract did not induce any change in the mRNA expression of the TIMP-1, -2 and -4 in HepG2 and TIMP-1, -2, -3 and -4 in MDA-MB231 cells. Activator protein-1 (AP-1)-dependent c-Jun-mediated transcriptional regulation of MMP-1, -2, and -9 was also studied to elucidate the appropriate mechanism involved in the inhibition of MMPs. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |