Phytochemical Name : Chinese propolis extract (CPWE)

Properties Information
PhytoCAT-ID PhytoCAT-1165
Phytochemical name or plant extracts Chinese propolis extract (CPWE)
PMID 27123037
Literature evidence To understand the material basis of antitumor activity of Chinese propolis water extract (CPWE), we developed a simple and efficient method using macroporous absorptive resin coupled with preparative high performance liquid chromatography and separated and purified eleven chemical components (caffeic acid, ferulic acid, isoferulic acid, 3,4-dimethoxycinnamic acid, pinobanksin, caffeic acid benzyl ester, caffeic acid phenethyl ester, apigenin, pinocembrin, chrysin, and galangin) from CPWE, then we tested the antitumor activities of these eleven components using different human tumor cell lines (MCF-7, MDA-MB-231, HeLa, and A549).
IUPAC name NA
Phytochemicals’ class or type of plant extracts Aqueous extract
Source of phytochemicals or plant Extracts Populus tremula
Geographical availability Albania, Algeria, Altay, Austria, Baltic States, Belarus, Belgium, Bulgaria, Central European Rus, China North-Central, China South-Central, China Southeast, Corse, Czechoslovakia, Denmark, East Aegean Is., East European Russia, East Himalaya, Finland, France, Germany, Great Britain, Greece, Hungary, Inner Mongolia, Ireland, Italy, Japan, Kamchatka, Kazakhstan, Korea, Krasnoyarsk, Kuril Is., Lebanon-Syria, Manchuria, Mongolia, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Portugal, Primorye, Qinghai, Romania, South European Russi, Spain, Sweden, Switzerland, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, Ukraine, West Siberia, Xinjiang, Yakutskiya, Yugoslavia
Plant parts Buds
Other cancers Breast cancer, Lung cancer, Colonic cancer
Target gene or protein Caspase 3
Gene or Protein evidence The major mechanism of inhibiting tumor cell proliferation of the seven effective components from CPWE was to induce apoptosis by activating caspase 3, the executor of apoptosis, and induce ROS production
Target pathways NA
IC50 NA
Potency The results indicated that the seven different components and CPWE significantly inhibited MDA-MB-231 cells migration at 48 h
Cell line/ mice model MCF-7, MDA-MB-231, HeLa, and A549
Additional information  Our study suggests that ethanol extract of Chinese propolis can be considered as a potential therapeutic agent in the treatment of early diabetic retinopathy.
PubChem ID NA
Additional PMIDs 30672592
Additional sources of information https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:302387-2
Safety NA