| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-763 | |
| Phytochemical name or plant extracts | Cheliensisin A | |
| PMID | 21775031 | |
| Literature evidence | Cheliensisin A is a natural styryl-lactone isolated from Goniothalamus cheliensis Hu in considerably large quantity with putative anticancer activities. | |
| IUPAC name | [(2R,3S)-6-oxo-2-[(2S,3R)-3-phenyloxiran-2-yl]-2,3-dihydropyran-3-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Styryl-lactone | |
| Source of phytochemicals or plant Extracts | Goniothalamus cheliensis | |
| Geographical availability | China South-Central, Laos, Thailand | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Liver cancer, Lung cancer, Pancreatic cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 20.31 μM against SKBR-3 | |
| Potency | NA | |
| Cell line/ mice model | SKBR-3, HL-60, SMMC-7721, A-549, PANC-1 | |
| Additional information | Collectively, we discover that Chel A treatment induces Beclin-dependent autophagy, consequently mediates PHLPP2 degradation and JNK/C-Jun phosphorylation and activation, further in turn contributing to apoptosis in human bladder cancer cells. | |
| PubChem ID | 56683717 | |
| Additional PMIDs | 27556506 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:73170-1 | |
| Safety | NA |