| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1333 | |
| Phytochemical name or plant extracts | Chelidonium majus extract | |
| PMID | 27350008 | |
| Literature evidence | CONCLUSIONS: These results indicate possible usefulness of Chelidonium majus crude extract in antitumor therapy, whether through its direct cytotoxic effect, by prevention of metastasis, or as adjuvant therapy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Chelidonium majus | |
| Geographical availability | Albania, Algeria, Altay, Amur, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Canary Is., Central European Rus, China North-Central, China South-Central, China Southeast, Chita, Corse, Czechoslovakia, Denmark, East European Russia, Finland, France, Germany, Greece, Hungary, Iran, Irkutsk, Italy, Kazakhstan, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Krym, Madeira, Manchuria, Mongolia, Morocco, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Portugal, Primorye, Qinghai, Romania, Sardegna, South European Russi, Spain, Sweden, Switzerland, Transcaucasus, Turkey, Turkey-in-Europe, Tuva, Ukraine, West Siberia, Yakutskiya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | For 24h, 48h: 143.61±5.87 µg/ml, 68.46±2.86 µg/ml against MDA-MB 231 respectively 179.35±9.92 µg/ml, 44.65±3.66 µg/ml against MCF-7 respectively | |
| Potency | These results indicate possible usefulness of Chelidonium majus crude extract in antitumor therapy, whether through its direct cytotoxic effect, by prevention of metastasis, or as adjuvant therapy. | |
| Cell line/ mice model | A549, H460, HCT 116, SW480, MDA-MB 231, MCF-7 | |
| Additional information | Chelidonium majus crude extract inhibits migration and induces cell cycle arrest and apoptosis in tumor cell lines. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:303589-2 | |
| Safety | NA |