| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1194 | |
| Phytochemical name or plant extracts | Chebulinic acid (CA) | |
| PMID | 32902904 | |
| Literature evidence | Annexin V/propidium iodide (PI) and active caspase-3 staining showed that CA was able to induce apoptosis in MDA-MB-231 cells but did not activate caspase-3. | |
| IUPAC name | 2-[(4R,5S,7R,8R,11S,12S,13S,21S)-13,17,18-trihydroxy-2,10,14-trioxo-5,21-bis[(3,4,5-trihydroxybenzoyl)oxy]-7-[(3,4,5-trihydroxybenzoyl)oxymethyl]-3,6,9,15-tetraoxatetracyclo[10.7.1.14,8.016,20]henicosa-1(19),16(20),17-trien-11-yl]acetic acid | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Terminalia chebula | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, East Himalaya, India, Laos, Myanmar, Nepal, Pakistan, Sri Lanka, Thailand, Vietnam, West Himalaya | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Bone cancer, Prostate cancer | |
| Target gene or protein | SOD1 | |
| Gene or Protein evidence | Chebulinic acid inhibits MDA-MB-231 breast cancer metastasis and promotes cell death through down regulation of SOD1 and induction of autophagy. | |
| Target pathways | CA indeed modulated the oxidative stress pathway | |
| IC50 | 55 uM against MDA-MB-231 | |
| Potency | Chebulinic acid (CA), a polyphenol derived from the fruits of various medicinal plants has potent anticancer activity. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, S115, HOS-1, PC-3 | |
| Additional information | Chebulinic acid (CA) is toxic to triple negative breast cancer cells and induces morphological changes indicating reduced aggressiveness. | |
| PubChem ID | 72284 | |
| Additional PMIDs | 12127233 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:171037-1 | |
| Safety | NA |