| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-887 | |
| Phytochemical name or plant extracts | Chamaejasmenin B | |
| PMID | 27374079 | |
| Literature evidence | Chamaejasmenin B, a novel candidate, inhibits breast tumor metastasis by rebalancing TGF-beta paradox. | |
| IUPAC name | (2S,3S)-3-[(2S,3S)-5,7-dihydroxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-methoxyphenyl)-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Stellera chamaejasme | |
| Geographical availability | Amur, Buryatiya, China North-Central, China South-Central, Chita, East Himalaya, Inner Mongolia, Korea, Manchuria, Mongolia, Nepal, Qinghai, Tibet, Xinjiang | |
| Plant parts | Roots | |
| Other cancers | Breast cancer | |
| Target gene or protein | β3 integrin-TβRII, TGF-beta | |
| Gene or Protein evidence | Mechanism study further revealed that ICJ efficiently blocked TGF-beta induced EMT, disrupted the interaction between β3 integrin-TβRII complex and, consequently, resulted in the selective inhibition of FAK:Src:p38 pathway. | |
| Target pathways | FAK:Src:p38 pathway | |
| IC50 | NA | |
| Potency | Importantly, in contrast with the antagonistic effects on TGF-beta induced metastasis, ICJ obviously sensitized its cytostatic activity, suggesting that it was not a pan-blocker but a rebalancer for the functional output of TGF-beta. Collectively, by targeting TGF-beta Paradox, we experimentally provided a promising candidate for metastatic intervention. | |
| Cell line/ mice model | MDA-MB-231, ZR75-1 and 4T1 | |
| Additional information | Collectively, our study revealed that ICJ rebalanced macrophage polarization in malignant microenvironment and showed promising effect in suppressing metastatic outgrowth in breast cancer model. | |
| PubChem ID | 21676273 | |
| Additional PMIDs | 23222270 35027915 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:832760-1 | |
| Safety | Moreover, by dynamical quantification of breast cancer progression in small-animal imaging system, ICJ was proved to be a potent inhibitor of metastasis with minimal toxic side effects. |