| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-124 | |
| Phytochemical name or plant extracts | Centaurea bruguierana | |
| PMID | 32700127 | |
| Literature evidence | Overall, our results demonstrated that CB EtOAc showed apoptosis-inducing effects, suggesting that C. bruguierana may be a promising source for a novel chemotherapeutic agents for the treatment of breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Centaurea bruguierana | |
| Geographical availability | Afghanistan, India, Iran, Iraq, Kazakhstan, Kuwait, Lebanon-Syria, Pakistan, Saudi Arabia, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan, Uzbekistan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, Caspase 3, Caspase 9 | |
| Gene or Protein evidence | The induction of apoptosis by CB EtOAc in MCF-7 cells was also associated with an increase in the Bax/Bcl-2 ratio and higher expression of caspases. | |
| Target pathways | NA | |
| IC50 | 10 μg/mL against MCF-7 | |
| Potency | Of all fractions, CB EtOAc was found to have the strongest antiproliferative activity (IC50 = 10 μg/mL) against MCF-7 cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Overall, our results demonstrated that CB EtOAc showed apoptosis-inducing effects, suggesting that C. bruguierana may be a promising source for a novel chemotherapeutic agents for the treatment of breast cancer. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:190084-1 | |
| Safety | NA |