| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1336 | |
| Phytochemical name or plant extracts | Cedrelone | |
| PMID | 22277739 | |
| Literature evidence | Cedrelone (13) and dysobinin (18) showed significant cytotoxicity, and toonayunnanin B (2) and epoxyazadiradione (14), were found to be slightly cytotoxic against the above cell lines. | |
| IUPAC name | (1R,2R,4R,6S,7S,10R,11R)-6-(furan-3-yl)-17-hydroxy-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadeca-12,16-diene-14,18-dione | |
| Phytochemicals’ class or type of plant extracts | Limonoid | |
| Source of phytochemicals or plant Extracts | Toona ciliata, Trichilia catigua | |
| Geographical availability | Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nepal, New Guinea, Pakistan, Philippines, Sulawesi, Sumatera, Thailand, Vietnam, West Himalaya Argentina Northeast, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Paraguay | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Leukemia, Liver cancer, Lung cancer, Colon cancer | |
| Target gene or protein | EGFR, MMP9, MMP | |
| Gene or Protein evidence | These effects were concomitant with the downregulation of EGFR, ?1-integrin and phospho-Akt, which could have resulted in a decrease of NF-kappaB levels and MMP9 activity. The effects of cell migration and invasion on MDA-MB-231 cell may be explained, at least in part, by the ability of cedrelone to inhibit MMP activity | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | HL-60, SMMC-7721, A-549, MCF-7, SW480, MDA-MB-231 | |
| Additional information | Cedrelone acetate - a derivative, causes downregulation of EGFR, ?1-integrin and phospho-Akt, leading to a decrease of NF?B levels and MMP9 activity (MDA-MB-231 cells), inhibits MMP activity and inhibits proliferation, adhesion, migration and invasion of MDA-MB-231 cells | |
| PubChem ID | 21596358 | |
| Additional PMIDs | 23869780 31857088 22277739 33164370 26330216 28129886 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:579299-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:579374-1 | |
| Safety | NA |