| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-520 | |
| Phytochemical name or plant extracts | Caulis Spatholobi extract (SET) | |
| PMID | 27779702 | |
| Literature evidence | Extract of Caulis Spatholobi, a novel blocker targeting tumor cell‑induced platelet aggregation, inhibits breast cancer metastasis. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Spatholobus suberectus | |
| Geographical availability | Assam, China South-Central, China Southeast, East Himalaya, Laos, Thailand, Vietnam | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | At 3h, 6h, 12h, 24h: 2929.153 µg/ml against 4T1 1309.211 µg/ml against 4T1 132.26 µg/ml against 4T1 26.458 µg/ml against 4T1 | |
| Potency | NA | |
| Cell line/ mice model | 4T1 / mice model | |
| Additional information | For the molecular mechanism study of anti‑TCIPA, zymography and RT‑PCR assay preliminarily revealed the molecular mechanism of SET in the regulation of P‑T interaction. Collectively, through drug efficacy identification and pharmacological revealing, we have obtained a promising candidate for the interference of breast metastasis by suppressing TCIPA, which will be beneficial for clinical cancer treatment. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:519185-1 | |
| Safety | NA |