| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-29 | |
| Phytochemical name or plant extracts | Caudatin | |
| PMID | 31102888 | |
| Literature evidence | BACKGROUND: The ability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to preferentially induce apoptosis in transformed cells while sparing most normal cells is well established. | |
| IUPAC name | [(3S,8S,9R,10R,12R,13S,14R,17R)-17-acetyl-3,8,14,17-tetrahydroxy-10,13-dimethyl-1,2,3,4,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-12-yl] (E)-3,4-dimethylpent-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Steroidal glycosides | |
| Source of phytochemicals or plant Extracts | Cynanchum auriculatum | |
| Geographical availability | China South-Central, East Himalaya, Nepal, Pakistan, Tibet, West Himalaya | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | DR5, CHOP, p38 MAPK, JNK | |
| Gene or Protein evidence | Our results showed that caudatin sensitized breast cancer cells to TRAIL-induced apoptosis through activation of CHOP, p38 MAPK and JNK-mediated upregulation of DR5 expression. | |
| Target pathways | GR-YAP signaling pathway | |
| IC50 | NA | |
| Potency | The combination of TRAIL and caudatin may be a promising therapeutic approach for the treatment of breast cancer. | |
| Cell line/ mice model | MDA-MB-231, MCF-7/ nude mouse | |
| Additional information | Caudatin treatment induced Ub-dependent GR degradation and blocked subsequent YAP nuclear accumulation and target gene (CTGF and CYR61) transcription signals in BCSCs. These results suggest that the GR/YAP signaling pathway regulates BCSC formation and that caudatin may be a potential anticancer agent that targets breast cancer cells and BCSCs. Caudatin inhibited breast cancer cell proliferation, mammosphere formation and tumor growth. | |
| PubChem ID | 72948694 | |
| Additional PMIDs | 32570844 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:102680-1 | |
| Safety | NA |