| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-181 | |
| Phytochemical name or plant extracts | Casearin G | |
| PMID | 24522418 | |
| Literature evidence | BACKGROUND: The rainforest is an important source of natural compounds with therapeutic properties. | |
| IUPAC name | [(1S,3R,5R,6aS,7S,8S,9S,10aS)-1-acetyloxy-9-butoxy-5-methoxy-7,8-dimethyl-7-[(2E)-3-methylpenta-2,4-dienyl]-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-3-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Casearia sylvestris | |
| Geographical availability | Argentina Northeast, Argentina Northwest, Belize, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Cayman Is., Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, French Guiana, Guatemala, Guyana, Haiti, Honduras, Jamaica, Leeward Is., Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Paraguay, Peru, Puerto Rico, Suriname, Trinidad-Tobago, Uruguay, Venezuela, Windward Is. | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 112.8 µM against MCF-7 | |
| Potency | GI50 = 11.8 µM | |
| Cell line/ mice model | PC-3, MCF-7 | |
| Additional information | These observations indicate that lupeol and casearin G might be useful compounds in the preparation of anti-inflammatory drugs, whereas casearin G might be useful in the elaboration of antitumor drugs. | |
| PubChem ID | 101602066 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:274165-2 | |
| Safety | LC50 = 49.4 µM |