| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-781 | |
| Phytochemical name or plant extracts | Carvacrol | |
| PMID | 33163084 | |
| Literature evidence | A multilevel computational study to evaluate the antitumor potential of carvacrol focusing on the main targets involved in the breast cancer was carried out. | |
| IUPAC name | 2-methyl-5-propan-2-ylphenol | |
| Phytochemicals’ class or type of plant extracts | Phenol monoterpene | |
| Source of phytochemicals or plant Extracts | Xylopia aromatica | |
| Geographical availability | Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Colombia, Costa Rica, Cuba, French Guiana, Guyana, Honduras, Nicaragua, Panamá, Paraguay, Peru, Suriname, Trinidad-Tobago, Venezuela | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | TRPM7 | |
| Gene or Protein evidence | A naturally derived transient receptor potential melastatin-like 7 channel (TRPM7) inhibitor, carvacrol, was found to have anti-cancer potentials. | |
| Target pathways | We hypothesized that carvacrol affects breast cancer cells through TRPM7 mediated cell cycle regulation. mTOR signaling pathway | |
| IC50 | NA | |
| Potency | Additionally, in silico drug-likeness index for carvacrol showed a good predicted therapeutic profile of druggability. Our findings suggest that mTOR signaling pathway could be responsible for its preventive effect in the breast cancer. | |
| Cell line/ mice model | BT-483, BT-474, MCF-7, MDA-MB-231, and MDA-MB-453 | |
| Additional information | It has been shown that carvacrol has antiproliferative properties on non-small-cell lung cancer cells, A549, chronic myeloid leukemia cells, K562, Hep-2 cells, murine B16 melanoma cells, and human metastatic breast cancer cells, MDA-MB231 | |
| PubChem ID | 10364 | |
| Additional PMIDs | 35253124 33310045 24812569 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:76067-1 | |
| Safety | NA |