| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-122 | |
| Phytochemical name or plant extracts | Carpesium abrotanoides extract | |
| PMID | 31750963 | |
| Literature evidence | These findings indicate that PCA is a promising agent with practical applications in the development of functional food containing Carpesium abrotanoides L. root extracts. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Petroleum ether extract | |
| Source of phytochemicals or plant Extracts | Carpesium abrotanoides | |
| Geographical availability | Afghanistan, Albania, Altay, Austria, Belgium, Bulgaria, China North-Central, China South-Central, China Southeast, Czechoslovakia, East Himalaya, Georgia, Germany, Greece, Hainan, Hungary, Iran, Iraq, Italy, Japan, Kazakhstan, Korea, Nepal, Netherlands, North Caucasus, Pakistan, Poland, Romania, Switzerland, Taiwan, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, West Himalaya, Xinjiang, Yugoslavia | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | PKM2 | |
| Gene or Protein evidence | Moreover, PCA downregulated the expression of pyruvate kinase M2 and altered its cellular translocation. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | We also demonstrated PCA is an inhibitor of the PKM2/hypoxia-inducible factor-1α axis, indicating that PCA is potentially useful as an anti-breast cancer agent. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | These findings indicate that PCA is a promising agent with practical applications in the development of functional food containing Carpesium abrotanoides L. root extracts. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:189330-1 | |
| Safety | NA |