| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1471 | |
| Phytochemical name or plant extracts | Caroguaianolide A | |
| PMID | 29621599 | |
| Literature evidence | All isolated compounds (1-14) were tested in vitro for their cytotoxic activities against the MDA-MB-231, HGC-27 cancer cell lines, of which compounds 1-3, 6, 7, 11 and 12 showed significant cytotoxic activities with IC50 values ranging from 2.67 to 12.34 μM. | |
| IUPAC name | (4R,5R,7R,8S) 4?-hydroxy-9-oxo-5?H-1(10),11(13)-guaien-8?,12-olide | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactones | |
| Source of phytochemicals or plant Extracts | Carpesium abrotanoides | |
| Geographical availability | Afghanistan, Albania, Altay, Austria, Belgium, Bulgaria, China North-Central, China South-Central, China Southeast, Czechoslovakia, East Himalaya, Georgia, Germany, Greece, Hainan, Hungary, Iran, Iraq, Italy, Japan, Kazakhstan, Korea, Nepal, Netherlands, North Caucasus, Pakistan, Poland, Romania, Switzerland, Taiwan, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, West Himalaya, Xinjiang, Yugoslavia | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Stomach cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 7.96 ± 0.66 µM against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | HGC-27, MDA-MB-231 | |
| Additional information | Shows significant cytotoxic activities against MDA-MB-231, HGC-27 cells | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:189330-1 | |
| Safety | NA |