| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1175 | |
| Phytochemical name or plant extracts | Carnosol | |
| PMID | 31456939 | |
| Literature evidence | We show that blockade of proteasome activity, by MG-132 and bortezomib, or ROS accumulation, by N-acetylcysteine (NAC), restored the level of STAT3 protein. | |
| IUPAC name | (1R,8S,10S)-3,4-dihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[6.6.2.01,10.02,7]hexadeca-2,4,6-trien-15-one | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Rosmarinus officinalis | |
| Geographical availability | Albania, Algeria, Baleares, Corse, Cyprus, East Aegean Is., Egypt, France, Greece, Italy, Libya, Morocco, Portugal, Sardegna, Sicilia, Spain, Tunisia, Turkey, Yugoslavia | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | STAT-3, MMP9, Cyclin B1 | |
| Gene or Protein evidence | This is the first report which shows that carnosol specifically targets signal transducer and activator of transcription 3 (STAT3) for proteasome degradation in breast cancer. Furthermore, gelatin zymography, ELISA, and RT-PCR assays revealed that carnosol inhibited the activity and downregulation the expression of MMP-9. In contrast, treatment with CA and CSOL resulted in cytostatic G2/M arrest and an increase in cyclin B1 expression; thus, naturally-occurring rosemary and its constitutive terpenoids re-establish homeostatic control of proliferation and decrease cancer risk via distinct mechanisms. | |
| Target pathways | We demonstrated that carnosol exerts its effect against breast cancer, at least partly, through downregulation of the activity and the expression of MMP-9, inhibition of STAT3 signaling pathway through a ROS-dependent proteasome degradation of STAT3 protein. we show that carnosol induced DNA damage, reduced the mitochondrial potential and triggered the activation of the intrinsic and extrinsic apoptotic pathway. | |
| IC50 | 25.6 µM against MCF-7 | |
| Potency | Our study further provide evidence that carnosol may represent a promising therapeutic candidate that canmodulate breast cancer growth and metastasis. | |
| Cell line/ mice model | MDA-MB-231, Hs578T, MCF-7,T47D | |
| Additional information | We found that carnosol induced a dose-dependent generation of reactive oxygen species (ROS) and inhibition of ROS by tiron, a ROS scavenger, blocked the induction of autophagy and apoptosis and attenuated DNA damage..Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer | |
| PubChem ID | 442009 | |
| Additional PMIDs | 34055630 25299698 30214619 20736335 31456939 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:455509-1 | |
| Safety | NA |