| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-936 | |
| Phytochemical name or plant extracts | Cardamonin | |
| PMID | 31393045 | |
| Literature evidence | Cardamonin (CD), a naturally occurring chalcone isolated from large black cardamom, was previously reported to suppress the proliferation of breast cancer cells. | |
| IUPAC name | (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one | |
| Phytochemicals’ class or type of plant extracts | Chalcone | |
| Source of phytochemicals or plant Extracts | Amomum subulatum | |
| Geographical availability | Assam, Bangladesh, China South-Central, China Southeast, East Himalaya, India, Myanmar, Nepal, Tibet | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | FOXO3a, p21, p27, Bim | |
| Gene or Protein evidence | We showed that CD enhanced the expression and nuclear translocation of Forkhead box O3 (FOXO3a) via upstream c-Jun N-terminal kinase, inducing the expression of FOXO3a and its target genes, including p21, p27, and Bim. | |
| Target pathways | JNK-FOXO3a pathway | |
| IC50 | NA | |
| Potency | In vivo, CD efficiently suppressed the growth of MDA-MB 231 breast cancer xenograft tumors. Taken together, our data provide a molecular mechanistic rationale for CD-induced cell cycle arrest and apoptosis in breast cancer cells. | |
| Cell line/ mice model | MDA-MB 231 and MCF-7 | |
| Additional information | The addition of NAC markedly reversed these effects, knockdown of FOXO3a using small interfering RNA also decreased CD-induced G2/M arrest and apoptosis. | |
| PubChem ID | 641785 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:872166-1 | |
| Safety | NA |