| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1076 | |
| Phytochemical name or plant extracts | Capsicum annuum extract (CAP) | |
| PMID | 30241820 | |
| Literature evidence | Further studies are encouraged to better understand the CAP potential for the treatment of breast tumors. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Pectic polysaccharides | |
| Source of phytochemicals or plant Extracts | Capsicum annuum | |
| Geographical availability | Arizona, Bahamas, Belize, Bolivia, Brazil North, Brazil Northeast, Cayman Is., Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, Florida, Guatemala, Guyana, Haiti, Honduras, Jamaica, Leeward Is., Louisiana, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Netherlands Antilles, Nicaragua, Panamá, Peru, Puerto Rico, Southwest Caribbean, Suriname, Texas, Trinidad-Tobago, Turks-Caicos Is., Venezuela, Windward Is. | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | VEGF | |
| Gene or Protein evidence | CAP inhibited the gene expression of VEGF in MCF-7 (-24%) and MDA-MB-436 (-39%) cells but not in MDA-MB-231 cells | |
| Target pathways | NA | |
| IC50 | 0.71 mg/ml against MCF-7 2.27 mg/ml against MDA-MB-231 | |
| Potency | Importantly, all these cell lineages have a mammary origin, indicating that green sweet pepper polysaccharides may have the potential to treat breast cancer. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, MDA-MB-435 | |
| Additional information | Capsicum can be used topically to treat pain associated with osteoarthritis, shingles, rheumatoid arthritis, post-herpetic neuralgia, trigeminal neuralgia, diabetic neuropathy, fibromyalgia, and back pain. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:316944-2 | |
| Safety | NA |