| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-112 | |
| Phytochemical name or plant extracts | Capillarisin | |
| PMID | 18088599 | |
| Literature evidence | Capillarisin has been found to suppress PMA-induced MMP-9 expression through inhibition of the NF-kappaB-dependent transcriptional activity of MMP-9 gene via p38 MAPK and JNK signaling pathways. | |
| IUPAC name | 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Artemisia capillaris | |
| Geographical availability | Assam, China North-Central, China South-Central, China Southeast, Hainan, Inner Mongolia, Irkutsk, Japan, Korea, Manchuria, Mongolia, Nansei-shoto, Pakistan, Primorye, Qinghai, Tibet, West Himalaya, Xinjiang | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP9 | |
| Gene or Protein evidence | Capillarisin has been found to suppress PMA-induced MMP-9 expression through inhibition of the NF-kappaB-dependent transcriptional activity of MMP-9 gene via p38 MAPK and JNK signaling pathways. | |
| Target pathways | p38 MAPK and JNK signaling pathways | |
| IC50 | NA | |
| Potency | These results suggest that capillarisin represents a potential anti-metastatic agent suppressing cancer cell invasion through specific inhibition of NF-kappaB-dependent MMP-9 gene expression. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Capillarisin has extensive pharmacological properties and has been considered to have promising ant-inflammatory and anti-nociceptive activities. | |
| PubChem ID | 5281342 | |
| Additional PMIDs | 24495472 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:179314-1 | |
| Safety | NA |