| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1705 | |
| Phytochemical name or plant extracts | Candidone | |
| PMID | 31814840 | |
| Literature evidence | Expression levels of ABCG2 and P-gp were not significantly downregulated by these flavonoids. | |
| IUPAC name | (2S)-5,7-dimethoxy-8-(3-methylbut-2-enyl)-2-phenyl-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoids | |
| Source of phytochemicals or plant Extracts | Tephrosia candida, Pongamia pinnata,onchocarpus costaricensis | |
| Geographical availability | E. Asia - India, Nepal, Bhutan, E. Asia - Indian subcontinent, through south-east Asia to north-eastern Australia, Fiji and Japan, Costa Rica | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Stomach cancer | |
| Target gene or protein | ABCG2 | |
| Gene or Protein evidence | Flavonoids did not reduce mRNA expression of P-gp and ABCG2 after 72Â h treatment, except Candidone in EPG85.257RDB | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | IC10 - 1338.6 ± 114.11 nM, 730 ± 258 nM (EPG85.257RDB) IC10 - 27.9 ± 5.59 nM, 3340 ± 622 nM (MCF7/MX) | |
| Cell line/ mice model | MCF-7/MX, EPG85.257RDB | |
| Additional information | Decreases the viability of MCF7/MX and EPG85.257RDB cells and significantly (p < 0.05) decreases IC50 of daunorubicin and mitoxantrone in MCF7/MX cells - displays high potency to sensitize MDR cells to daunorubicin and mitoxantrone, and cytotoxicity in MCF7/MX and EPG85.257RDB cells at IC10 of the compound | |
| PubChem ID | 157102 | |
| Additional PMIDs | 34564803 | |
| Additional sources of information | NA | |
| Safety | NA |