| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-884 | |
| Phytochemical name or plant extracts | Camellianin A | |
| PMID | 20657414 | |
| Literature evidence | In the anticancer assay, it was found camellianin A could inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 and human breast adenocarcinoma MCF-7 cell lines in a dose-dependent manner and induce the significant increase of the G0/G1 cell population. | |
| IUPAC name | [(2R,3S,4R,5R,6S)-4,5-dihydroxy-6-[7-hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-5-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methyl acetate | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Adinandra nitida | |
| Geographical availability | China South-Central, China Southeast | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Camellianin A induced a dose-dependent inhibitory effect. Nearly 33.8%, 8.7% of MCF-7 and Hep G2 cells were inhibited by 200 μM camellianin A. Compared with Hep G2 cells, inhibition of MCF-7 cell proliferation by camellianin A was more effective. | |
| Cell line/ mice model | MCF-7, HepG2 | |
| Additional information | The increase of an early apoptotic population of Hep G2 and MCF-7 cells was observed. It was concluded that camellianin A not only affected the progress of the cell cycle, but also induced cells to enter into apoptosis. | |
| PubChem ID | 5487343 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:829817-1 | |
| Safety | NA |