| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-882 | |
| Phytochemical name or plant extracts | Camellia sinensis extract | |
| PMID | 24561153 | |
| Literature evidence | Western blot analysis showed that CS increased the expression of Bax-to-Bcl-2 ratio and activated caspase-8 and caspase-3 to induce apoptosis. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Camellia sinensis | |
| Geographical availability | Assam, China South-Central, China Southeast, East Himalaya, Hainan, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, Caspase 8, Caspase 3 | |
| Gene or Protein evidence | Western blot analysis showed that CS increased the expression of Bax-to-Bcl-2 ratio and activated caspase-8 and caspase-3 to induce apoptosis. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | CS aqueous extract, which closely mimics green tea beverage, has potent antitumor and antimetastasis effects in breast cancer and could protect the bone from breast cancer-induced bone destruction. | |
| Cell line/ mice model | 4T1/ BALB/c mice | |
| Additional information | Apart from the antitumor effect, CS extract significantly decreased lung and liver metastasis in BALB/c mice bearing 4T1 tumors by 54.5% and 72.6%, respectively. | |
| PubChem ID | NA | |
| Additional PMIDs | 31816463 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:828548-1 | |
| Safety | NA |