| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-184 | |
| Phytochemical name or plant extracts | Camalexin | |
| PMID | 23179315 | |
| Literature evidence | In conclusion, camalexin is more potent in aggressive prostate cancer cells that express high ROS levels, and this phytoalexin has a strong potential as a novel therapeutic agent for the treatment of especially metastatic prostate cancer. | |
| IUPAC name | 2-(1H-indol-3-yl)-1,3-thiazole | |
| Phytochemicals’ class or type of plant extracts | Indole phytoalexin | |
| Source of phytochemicals or plant Extracts | Arabidopsis thaliana | |
| Geographical availability | Afghanistan, Albania, Algeria, Altay, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Canary Is., Cape Verde, Central European Russia, China North-Central, China South-Central, China Southeast, Corse, Cyprus, Czechoslovakia, Denmark, Djibouti, East Aegean Is., East European Russia, East Himalaya, Eritrea, Ethiopia, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Ireland, Italy, Japan, Kazakhstan, Kenya, Kirgizstan, Korea, Krasnoyarsk, Kriti, Krym, Lebanon-Syria, Libya, Madeira, Mongolia, Morocco, Nepal, Netherlands, North Caucasus, North European Russia, Northwest European Russia, Norway, Pakistan, Palestine, Poland, Portugal, Romania, Rwanda, Sardegna, Saudi Arabia, Sicilia, Somalia, South European Russia, Spain, Sudan, Sweden, Switzerland, Tadzhikistan, Tanzania, Tibet, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Tuva, Uganda, Ukraine, Uzbekistan, West Himalaya, West Siberia, Xinjiang, Yugoslavia, Zaïre | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | This compound has been researched predominantly with regard to plant chemical defense mechanisms, and has been shown to exert cytostatic/cytotoxic effects on the human protozoan pathogen Trypanosoma cruzi [31] and on the human breast cancer cell line SKBr3, where it displays higher potency than the traditional anticancer agents cisplatin and melphalan | |
| Cell line/ mice model | SKBR-3, PREC | |
| Additional information | This compound has been researched predominantly with regard to plant chemical defense mechanisms, and has been shown to exert cytostatic/cytotoxic effects on the human protozoan pathogen Trypanosoma cruzi and on the human breast cancer cell line SKBr3, where it displays higher potency than the traditional anticancer agents cisplatin and melphalan | |
| PubChem ID | 636970 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:277970-1 | |
| Safety | NA |