| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1798 | |
| Phytochemical name or plant extracts | Calycosin | |
| PMID | 23609007 | |
| Literature evidence | And for the first time, this study revealed that calycosin may have potential as a therapeutic agent for the treatment of breast cancer. © Georg Thieme Verlag KG Stuttgart · New York. | |
| IUPAC name | 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Radix astragali | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | RASD1, Bax, Bcl-2 | |
| Gene or Protein evidence | The results showed that high concentrations of calycosin significantly suppressed the proliferation of MCF-7 cells and promoted cell apoptosis. Moreover, compared with control group, the expression of Bcl-2 decreased with calycosin in MCF-7 cells, while Bax increased, which was significantly correlated with elevated expression of RASD1. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | And for the first time, this study revealed that calycosin may have potential as a therapeutic agent for the treatment of breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Calycosin was also rapidly and extensively metabolized to 3'-glucuronide in the enterocytes and liver, and the glucuronidation rates of calycosin and CG were much higher in the former. | |
| PubChem ID | 5280448 | |
| Additional PMIDs | 34096887 26658676 | |
| Additional sources of information | NA | |
| Safety | acute toxic in pubmed database |