| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-773 | |
| Phytochemical name or plant extracts | Calycopterin | |
| PMID | 32617603 | |
| Literature evidence | Calycopterin is a flavonoid which was shown to induce preferential antiproliferative effects on some cancers, however, no information is available on its effect on breast cancer. | |
| IUPAC name | 5-hydroxy-2-(4-hydroxyphenyl)-3,6,7,8-tetramethoxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Dracocephalum kotschyi | |
| Geographical availability | Iran | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2 | |
| Gene or Protein evidence | Gene expression revealed that Bax/Bcl2 increased in the MDA-MB-231 cell line, while no change was observed in that of the MCF7 line. | |
| Target pathways | Mitochondrial pathway | |
| IC50 | 150 μM against MDA-MB-231, 30 μM against MCF-7 | |
| Potency | Expression of gene caspase-8 was augmented in both lines, although increased expression of caspase-3 was found just in MDA-MB-231 cells. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Our results validated the apoptotic effect of calycopterin on both breast cancer lines with more potency on triple-negative ones. | |
| PubChem ID | 10429470 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:446450-1 | |
| Safety | NA |