| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-7 | |
| Phytochemical name or plant extracts | Calotropis procera extract | |
| PMID | 28951762 | |
| Literature evidence | Ethanol extracts of the three parts of C. procera were evaluated for their antiulcer activity and we found that the leaf extract possessed a powerful antiulcer activity which could be considered as a promising drug candidate. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Calotropis procera | |
| Geographical availability | Afghanistan, Algeria, Assam, Bangladesh, Benin, Burkina, Cambodia, Cameroon, Canary Is., Cape Verde, Central African Repu, Chad, Congo, Djibouti, East Himalaya, Egypt, Eritrea, Ethiopia, Gambia, Ghana, Guinea, Guinea-Bissau, Gulf of Guinea Is., Gulf States, India, Iran, Ivory Coast, Kenya, Kuwait, Lebanon-Syria, Libya, Malawi, Mali, Mauritania, Morocco, Mozambique, Myanmar, Nepal, Niger, Nigeria, Oman, Pakistan, Palestine, Saudi Arabia, Senegal, Sierra Leone, Sinai, Socotra, Somalia, Sudan, Tanzania, Thailand, Tunisia, Uganda, Vietnam, Western Sahara, Yemen, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Leaves, flowers, fruits, roots | |
| Other cancers | Breast cancer, Colorectal cancer, Lung cancer | |
| Target gene or protein | Bcl-2 | |
| Gene or Protein evidence | Based on the results of flow cytometry and western blotting, IC50 concentration of the extract induced significant apoptosis in the studied cell line, possibly through down-regulation of Bcl-2 expression. | |
| Target pathways | NA | |
| IC50 | Ethanol leaf extract = 98.20 ± 8.32 µg/mL against MCF-7 Ethanol flower extract = 68.20 ± 8.54 µg/mL against MCF-7 Ethanol fruit extract = 49.70 ± 4.10 µg/mL against MCF-7 | |
| Potency | Ethanol extracts of the three parts of C. procera were evaluated for their antiulcer activity and we found that the leaf extract possessed a powerful antiulcer activity which could be considered as a promising drug candidate. | |
| Cell line/ mice model | MCF-7, HCT-116, HepG-2, A-549 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 34345386 34119813 17604595 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1004515-2 | |
| Safety | NA |