| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-345 | |
| Phytochemical name or plant extracts | Calophyllum inophyllum extract | |
| PMID | 29068745 | |
| Literature evidence | This is evidenced by the elevation of intracellular ROS, the loss of mitochondria membrane potential (Δψm), and activation of caspase-3. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Calophyllum inophyllum | |
| Geographical availability | Aldabra, Andaman Is., Bangladesh, Bismarck Archipelago, Borneo, Cambodia, Caroline Is., Chagos Archipelago, Christmas I., Cocos (Keeling) Is., Comoros, Cook Is., Fiji, Gilbert Is., Hainan, Hawaii, India, Jawa, Kazan-retto, Kenya, Laccadive Is., Laos, Lesser Sunda Is., Madagascar, Malaya, Maldives, Maluku, Marianas, Marshall Is., Mauritius, Mozambique, Mozambique Channel I, Myanmar, Nansei-shoto, Nauru, New Caledonia, New Guinea, Nicobar Is., Niue, Ogasawara-shoto, Philippines, Queensland, Rodrigues, Réunion, Samoa, Santa Cruz Is., Seychelles, Solomon Is., South China Sea, Sri Lanka, Sulawesi, Sumatera, Taiwan, Tanzania, Thailand, Tokelau-Manihiki, Tonga, Tuvalu, Vanuatu, Vietnam, Wallis-Futuna Is. | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Colon cancer, Lung cancer | |
| Target gene or protein | Bcl-2, Bax, Cyt-c, p53, Caspase 3 | |
| Gene or Protein evidence | The expression of anti-apoptotic proteins Bcl-2 was decreased whereas the expression of the pro-apoptotic protein Bax, cytochrome C and p53 were increased after treatment. C. inophyllum fruit extract led to apoptosis in MCF-7 cells via the mitochondrial pathway in a dose dependent manner. This study shows that C. inophyllum fruits extract-induced apoptosis is primarily p53 dependent and mediated through the activation of caspase-3. | |
| Target pathways | Mitochondrial pathway | |
| IC50 | 23.59 µg/mL against MCF-7 | |
| Potency | C. inophyllum fruit extract could be an excellent source of chemopreventive agent in the treatment of breast cancer and has potential to be explored as green anticancer agent. | |
| Cell line/ mice model | MCF-7 cells | |
| Additional information | The expression of anti-apoptotic proteins Bcl-2 was decreased whereas the expression of the pro-apoptotic protein Bax, cytochrome C and p53 were increased after treatment. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:427190-1 | |
| Safety | NA |