| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-121 | |
| Phytochemical name or plant extracts | Calendula arvensis L. extract | |
| PMID | 30756331 | |
| Literature evidence | Based on our data, the CAF EtOAC may provide active ingredients for the development of novel chemotherapeutics for breast cancer therapy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethyl acetate extract | |
| Source of phytochemicals or plant Extracts | Calendula arvensis | |
| Geographical availability | Afghanistan, Albania, Algeria, Austria, Azores, Baleares, Baltic States, Belgium, Bulgaria, Canary Is., Cape Verde, Chad, Corse, Cyprus, Czechoslovakia, East Aegean Is., Egypt, France, Germany, Great Britain, Greece, Gulf States, Hungary, Iran, Iraq, Italy, Kriti, Krym, Kuwait, Lebanon-Syria, Libya, Madeira, Morocco, Netherlands, Oman, Pakistan, Palestine, Poland, Portugal, Romania, Sardegna, Saudi Arabia, Sicilia, Sinai, Spain, Sweden, Switzerland, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, West Himalaya, Yemen, Yugoslavia | |
| Plant parts | Flowers | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bax, Caspase 3, Caspase 7 | |
| Gene or Protein evidence | The same extract also caused apoptosis by downregulating Bcl-2 and upregulating Bax and caspase 3/7 activity. | |
| Target pathways | NA | |
| IC50 | 70 µg/mL against MCF-7 78 µg/mL against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Based on our data, the CAF EtOAC may provide active ingredients for the development of novel chemotherapeutics for breast cancer therapy. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:187819-1 | |
| Safety | NA |