| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1070 | |
| Phytochemical name or plant extracts | Cajanin stilbene acid | |
| PMID | 25716159 | |
| Literature evidence | In the present study, we investigated the activity and modes of action of cajanin stilbene acid (CSA) and its derivatives in terms of cytotoxicity, gene expression profile, and transcription factor activity. | |
| IUPAC name | 2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)-6-[(1E)-2-phenylethenyl]benzoic acid | |
| Phytochemicals’ class or type of plant extracts | Stilbene | |
| Source of phytochemicals or plant Extracts | Cajanus cajan | |
| Geographical availability | Assam, India, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | MYC | |
| Gene or Protein evidence | CSA and its derivatives are shown to be promising anticancer compounds with low toxicity. They inhibit MYC activity comparable to 10058-F4 and 10074-G5. | |
| Target pathways | NA | |
| IC50 | 54.77 ± 2.83 µM against MCF-7 | |
| Potency | Decreasing the c-MYC protein level in MCF-7 cells by RNAi significantly inhibited tumor growth both in vitro and in vivo, implying the therapeutic potential of RNAi for breast cancer treatment by targeting overexpressed oncogenes such as c-MYC. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Cajanin Stilbene Acid Inhibited Vancomycin-Resistant Enterococcus by Inhibiting Phosphotransferase System. | |
| PubChem ID | 9819225 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1152177-2 | |
| Safety | NA |