| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1730 | |
| Phytochemical name or plant extracts | Caffeic acid phenethyl ester (CAPE) | |
| PMID | 19394397 | |
| Literature evidence | Also, TAM treatment resulted in inhibition of hepatic activity of glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT). | |
| IUPAC name | 2-phenylethyl 3-(3,4-dihydroxyphenyl)prop-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Propolis, Euonymus alatus | |
| Geographical availability | E. Asia - Japan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | TLR4, MyD88, IRAK4, TRIF, NF-κB p65 | |
| Gene or Protein evidence | CONCLUSIONS: These findings indicated that EECP and its major constituent - CAPE inhibited breast cancer MDA-MB-231 cells proliferation in inflammatory microenvironment through activating apoptosis, autophagy and inhibiting TLR4 signaling pathway., TLR4 signaling pathway molecules such as TLR4, MyD88, IRAK4, TRIF and NF-κB p65 were all down-regulated after EECP and CAPE treatment in LPS-stimulated MDA-MB-231 cells. | |
| Target pathways | Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy. | |
| IC50 | 14.08 µM against MDA-MB-231 | |
| Potency | CAPE may markedly affect the viability of breast cancer cells, suggesting the potential role of bioactive compounds in chemoprevention/chemotherapy by potentiating the action of standard anti-cancer drugs. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, Hs578T, HaCaT | |
| Additional information | Caffeic acid phenethyl ester protects against tamoxifen-induced hepatotoxicity in rats. | |
| PubChem ID | 5281787 | |
| Additional PMIDs | 28950845 26007182 33014153 2450776 | |
| Additional sources of information | NA | |
| Safety | NA |