| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-933 | |
| Phytochemical name or plant extracts | Caffeic acid | |
| PMID | 9216644 | |
| Literature evidence | Chemosensitizing activity of caffeic acid in multidrug-resistant MCF-7/Dox human breast carcinoma cells. | |
| IUPAC name | (E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid | |
| Phytochemicals’ class or type of plant extracts | Hydroxycinnamic acids | |
| Source of phytochemicals or plant Extracts | Thalassodendron ciliatum | |
| Geographical availability | Aldabra, Andaman Is., Caroline Is., Chagos Archipelago, Cocos (Keeling) Is., Comoros, Djibouti, Egypt, Eritrea, Gulf States, Iran, Jawa, Kenya, KwaZulu-Natal, Lesser Sunda Is., Madagascar, Maldives, Maluku, Mauritius, Mozambique, Mozambique Channel I, New Guinea, Oman, Palestine, Philippines, Queensland, Saudi Arabia, Seychelles, Sinai, Socotra, Solomon Is., Somalia, Sudan, Sulawesi, Tanzania, Vanuatu, Yemen | |
| Plant parts | Seagras | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | MAPK signaling pathway | |
| IC50 | 17 μg/mL against MCF-7 | |
| Potency | EC50 1.7 ± 0.1mg/mL for DPPH and 1.1 ±0.2 mg/mL for ABTS. The tested compounds showed a time-dependent and dose-dependent inhibitory effect on cell growth with the following potency: caffeic acid > ferulic acid = protocatechuic acid = PAA > sinapic acid = syringic acid. | |
| Cell line/ mice model | MCF-7/Adr, MCF-7/wt, MDA-MB-231, T47D | |
| Additional information | The presence of caffeic acid or chlorogenic acid inhibited DNA methylation predominantly through a non-competitive mechanism, and this inhibition was largely due to the increased formation of S-adenosyl-L-homocysteine (SAH, a potent inhibitor of DNA methylation), resulting from the catechol-O-methyltransferase (COMT)-mediated O-methylation of these dietary catechols. | |
| PubChem ID | 689043 | |
| Additional PMIDs | 25141946 25738318 25691730 16081510 32959676 29562617 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:871797-1 | |
| Safety | NA |