| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-434 | |
| Phytochemical name or plant extracts | Butein | |
| PMID | 15848217 | |
| Literature evidence | The present study illustrated that butein was an aromatase inhibitor and a potential natural alternative for the chemoprevention or therapy of breast cancer. | |
| IUPAC name | (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one | |
| Phytochemicals’ class or type of plant extracts | Chalcone | |
| Source of phytochemicals or plant Extracts | Cyclopia subternata | |
| Geographical availability | Cape Provinces | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Aromatase | |
| Gene or Protein evidence | The present study illustrated that butein was an aromatase inhibitor and a potential natural alternative for the chemoprevention or therapy of breast cancer. | |
| Target pathways | NA | |
| IC50 | <5 μM against MCF-7 | |
| Potency | Subsequent enzyme kinetic study revealed that butein acted on aromatase with a mixed type of inhibition and the K(i) value was determined to be 0.32 microM. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | The present study illustrated that butein was an aromatase inhibitor and a potential natural alternative for the chemoprevention or therapy of breast cancer. | |
| PubChem ID | 5281222 | |
| Additional PMIDs | 15848217 19606519 22895548 34485148 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:489312-1 | |
| Safety | NA |