| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-429 | |
| Phytochemical name or plant extracts | Butea monosperma extract | |
| PMID | 30293450 | |
| Literature evidence | Bark fractions protect against free radicals and induce apoptosis in MCF-7 breast cancer cells via cell-cycle arrest and ROS-mediated pathway. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Chloroformic extract, ethyl acetate extract | |
| Source of phytochemicals or plant Extracts | Butea monosperma | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, China Southeast, East Himalaya, India, Laos, Myanmar, Nepal, Pakistan, Sri Lanka, Vietnam, West Himalaya | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Bchl and Beac were also observed to inhibit the growth of MCF-7 cells (GI50 203.7 and 246.5 µg/mL, respectively). | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Among all extract/fractions, a pronounced antioxidant activity was exhibited by Bchl and Beac fractions, in DPPH· (EC50 213.2 and 161.5 µg/mL, respectively), ABTS+· (EC50 139.3 and 44.1 µg/mL, respectively), and reducing power assay (EC50 86.7 and 84.5 µg/mL, respectively). | |
| PubChem ID | NA | |
| Additional PMIDs | 28207992 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:482566-1 | |
| Safety | NA |