| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-339 | |
| Phytochemical name or plant extracts | Bursera copallifera extract | |
| PMID | 29652200 | |
| Literature evidence | In some instances, secondary metabolites of these classes of compounds may induce cytotoxicity, and therefore we sought to investigate the effects of B. copallifera leaf extracts in breast cancer cell lines to evaluate their potential therapeutic value for the treatment of breast cancer, one of the most prevalent types of cancer in women worldwide. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Bursera copallifera | |
| Geographical availability | Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Southwest | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 34.88µg/mL against MCF7 12.43 µg/mL against MDA-MB-231 | |
| Potency | Our results strongly suggest a potential use of the Bursera leaf extracts rich in phenolic compounds, their individual phenolic compounds, or their combinations for the treatment of breast cancer. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Our results show that the B. copallifera extract inhibited cell migration in a wound assay in the highly metastatic MDA-MB-231 cell line but not in the MCF7 cell line , which is poorly metastatic in vivo.Decreased migration in the MDA-MB-231 cell line could be explained as decreased metastatic abilities or decreased proliferation ability which would later result in cell death. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:38569-2 | |
| Safety | NA |