| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-893 | |
| Phytochemical name or plant extracts | Bupleurum marginatum extract | |
| PMID | 24438177 | |
| Literature evidence | This study aims to investigate the antitrypanosomal, antimicrobial and antiviral activities of methanol (ME) and dichloromethane (DCM) extracts of B. marginatum aerial parts and the ability of both extracts to inhibit the growth of different cancer cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanol and Dichloromethane extract | |
| Source of phytochemicals or plant Extracts | Bupleurum marginatum | |
| Geographical availability | Afghanistan, Assam, Bangladesh, China North-Central, China South-Central, East Himalaya, Myanmar, Nepal, Pakistan, Qinghai, Tibet, West Himalaya | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Pancreatic cancer, Colon cancer, Leukemia | |
| Target gene or protein | Caspase 3, Caspase 7 | |
| Gene or Protein evidence | The cytotoxicity was mediated by induction of apoptosis (19-fold increase in the cellular caspase 3/7 level after treatment with the DCM extract at 1 mg/mL). | |
| Target pathways | NA | |
| IC50 | Methanolic extract - 91.18 ± 8.99 μg/mL against MCF-7 Dichloromethane extract - 51.00 ± 5.20 μg/mL against MCF-7 | |
| Potency | ME and DCM extract of B. marginatum showed anti-infective and antiproliferative effects. | |
| Cell line/ mice model | MCF-7, Caco-2, CCL-81, CCRF-CEM, COS-7, HL-60, MIA PaCa-2, PANC-1 | |
| Additional information | CCRF-CEM cells were the most sensitive to both extracts (IC50: 12.5-22.7 μg/mL). | |
| PubChem ID | NA | |
| Additional PMIDs | 19703352 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:839257-1 | |
| Safety | NA |