| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-202 | |
| Phytochemical name or plant extracts | Bryonolic acid | |
| PMID | 32498354 | |
| Literature evidence | The present study indicated that T. cucumerina L. cell cultures are alternative and efficient to produce the biologically important secondary metabolite. | |
| IUPAC name | (2S,4aS,6aS,8aR,10S,12aS,14aS,14bR)-10-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,3,4,5,6,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-2-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Trichosanthes cucumerina | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, China Southeast, East Himalaya, India, Jawa, Laccadive Is., Lesser Sunda Is., Maldives, Myanmar, Nepal, Northern Territory, Pakistan, Philippines, Queensland, Sri Lanka, Sulawesi, Thailand, Vietnam, West Himalaya, Western Australia | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Interestingly, cell culture and root extracts with high bryonolic acid contents resulted in significantly higher percent cell viabilities than those observed under control (1% v/v DMSO) treatment in Saos-2 and MCF-7 cells. | |
| Cell line/ mice model | SKBR-3, MCF-7, T47D, MDA-MB-435, A549, SK-LU1, Caco-2 | |
| Additional information | Bryonolic acid (1) inhibited MDA-MB435 somewhat better than the other tested human cancer cell lines. | |
| PubChem ID | 159970 | |
| Additional PMIDs | 32498354 19288406 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:294175-1 | |
| Safety | NA |