| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1858 | |
| Phytochemical name or plant extracts | Bruceine D | |
| PMID | 26071073 | |
| Literature evidence | Compounds 5, 7, 10 and 12 with a 3-hydroxy-3-en-2-one moiety showed potent inhibitory activities against the MCF-7 and MDA-MB-231 cells with IC50 values in the ranges 0.063-0.182 μM and 0.081-0.238 μM, respectively, while glycosidation at 3-OH significantly decreased the cytotoxicity. | |
| IUPAC name | (1R,2R,3R,6R,8S,12S,13S,14R,15R,16S,17R)-2,3,12,15,16-pentahydroxy-9,13,17-trimethyl-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-4,11-dione | |
| Phytochemicals’ class or type of plant extracts | Quassinoid | |
| Source of phytochemicals or plant Extracts | Brucea javanica | |
| Geographical availability | Andaman Is., Assam, Bismarck Archipelago, Borneo, Cambodia, Caroline Is., China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, New Guinea, Northern Territory, Philippines, Queensland, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Regulates the expression of E-cadherin and downregulates the expression of vimentin and β-catenin. Downregulates the expression of PI3K and reduces AKT phosphorylation, in MDA-MB-231 cells | |
| IC50 | 9.5 ± 7.7 μM against MCF-7 cells | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HS 578T | |
| Additional information | Inhibits MCF-7 and MDA-MB-231 cells proliferation and promotes cells apoptosis Causes inhibition of MCF-7 and HS 578T cell proliferation | |
| PubChem ID | 441788 | |
| Additional PMIDs | 32714860 3185329 35215292 31853299 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:813610-1 | |
| Safety | NA |