| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1759 | |
| Phytochemical name or plant extracts | Bruceine B | |
| PMID | 21910051 | |
| Literature evidence | Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells. | |
| IUPAC name | methyl (1R,2S,3R,6R,8R,13S,14R,15R,16S,17S)-3-acetyloxy-10,15,16-trihydroxy-9,13-dimethyl-4,11-dioxo-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Brucea javanica | |
| Geographical availability | Andaman Is., Assam, Bismarck Archipelago, Borneo, Cambodia, Caroline Is., China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, New Guinea, Northern Territory, Philippines, Queensland, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Leukemia, Liver cancer, Lung cancer, Colorectal cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 0.54 µM against MCF -7 | |
| Potency | Furthermore, these main compounds had significant antitumor effects in the cytotoxicity assay. | |
| Cell line/ mice model | HL-60, SMMC-7721, A-549, MCF -7, SW480 | |
| Additional information | Demonstrates significant inhibitory activities against HL-60, SMMC-7721, A-549, MCF-7, SW480 cells | |
| PubChem ID | 161496 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:813610-1 | |
| Safety | NA |