| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-852 | |
| Phytochemical name or plant extracts | Bruceantin | |
| PMID | 7113961 | |
| Literature evidence | All patients had received extensive prior therapy including adriamycin, cytoxan, 5-FU, methotrexate, and a vinca alkaloid. | |
| IUPAC name | methyl (1R,2S,3R,6R,8R,13S,14R,15R,16S,17S)-3-[(E)-3,4-dimethylpent-2-enoyl]oxy-10,15,16-trihydroxy-9,13-dimethyl-4,11-dioxo-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Brucea javanica | |
| Geographical availability | Andaman Is., Assam, Bismarck Archipelago, Borneo, Cambodia, Caroline Is., China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, New Guinea, Northern Territory, Philippines, Queensland, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam | |
| Plant parts | Twigs, Leaves, and inflorescence | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | A phase II evaluation of bruceantin was carried out in 15 patients with refractory metastatic breast cancer. | |
| Cell line/ mice model | MCF-7, Lu1, LNCaP | |
| Additional information | Hydnocarpin (8) showed a potentiating effect when combined with both 6 and 7, during cytotoxicity testing using the MCF-7 human breast cancer cell line. Compound 6 is Bruceantin | |
| PubChem ID | 5281304 | |
| Additional PMIDs | 19026551 7113961 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:813610-1 | |
| Safety | NA |