| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-854 | |
| Phytochemical name or plant extracts | Bruceae fructus oil (BO) | |
| PMID | 34658867 | |
| Literature evidence | Triple-negative breast cancer (TNBC) has been acknowledged as an aggressive disease with worst prognosis, which requires endeavor to develop novel therapeutic agents. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Vegetable oil | |
| Source of phytochemicals or plant Extracts | Brucea javanica | |
| Geographical availability | Andaman Is., Assam, Bismarck Archipelago, Borneo, Cambodia, Caroline Is., China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, New Guinea, Northern Territory, Philippines, Queensland, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | mTOR, 4E-BP1 | |
| Gene or Protein evidence | Moreover, the activity of mTOR in tumor was promoted by BO treatment as indicated by the phosphorylation of 4E-binding protein 1 (4E-BP1) and ribosomal protein S6, and hyper-autophagy was consequently restrained. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The present study highlighted a promising application of BO against breast cancer with novel efficacy and safety. | |
| Cell line/ mice model | MDA-MB-231 and BT-20 / Female Balb/c nude mice | |
| Additional information | By contrast, the failure of tumor suppression by BO under pseudo germ-free (PGF) condition came with indistinctive changes in autophagy and mTOR activity, implying the critical role of the gut microbiota in BO's anticancer activity. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:813610-1 | |
| Safety | NA |