| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-61 | |
| Phytochemical name or plant extracts | Bromelain proteinase (F9) | |
| PMID | 21559575 | |
| Literature evidence | The F9-induced PBL antitumor activity was dependent on the applied proteolytical activity and abolished when F9 was inactivated by iodoacetamide. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Proteinase | |
| Source of phytochemicals or plant Extracts | Ananas comosus | |
| Geographical availability | Argentina Northeast, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Colombia, Costa Rica, Ecuador, French Guiana, Guyana, Panamá, Paraguay, Peru, Suriname, Venezuela | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | IL- 2, TNF-a | |
| Gene or Protein evidence | In response to F9, the concentration of interleukin-2 (IL-2) and tumor necrosis factor-a increased 10 and 19 fold in the PBL supernatant, respectively. | |
| Target pathways | NA | |
| IC50 | The concentration, at 50% growth inhibition by F9, was in the range of 25-38 mug/ml at which the proteolytical activity of the added F9 was 2.5 U/mg. | |
| Potency | On the basis of the present study we suggest that F9 alone, or in combination with rIL-2, may be used as a potential biological response modifier in specific immunotherapy of distinct cancer diseases. | |
| Cell line/ mice model | MCF-7, SK-MEL-28 | |
| Additional information | F9 was found to synergize LAK cell activity in addition to suboptimal concentrations (0.625-2.5 U/ml) of rIL-2. F9 was also found to be growth inhibitory in the MTT assay, when it was directly added to the tumor cells: The concentration, at 50% growth inhibition by F9, was in the range of 25-38 mug/ml at which the proteolytical activity of the added F9 was 2.5 U/mg. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:12322-2 | |
| Safety | NA |