| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1745 | |
| Phytochemical name or plant extracts | Bromelain | |
| PMID | 21559575 | |
| Literature evidence | The F9-induced PBL antitumor activity was dependent on the applied proteolytical activity and abolished when F9 was inactivated by iodoacetamide. | |
| IUPAC name | N-[2-[5-acetamido-6-hydroxy-2-(hydroxymethyl)-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-3-yl]oxy-5-[4,5-dihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide | |
| Phytochemicals’ class or type of plant extracts | Protease | |
| Source of phytochemicals or plant Extracts | Ananas comosus | |
| Geographical availability | Argentina Northeast, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Colombia, Costa Rica, Ecuador, French Guiana, Guyana, Panamá, Paraguay, Peru, Suriname, Venezuela | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Squamous cancer, Skin cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our results with purified and fully active bromelain, ananain and papain show a strong reduction of cell proliferation with MDA-MB231 and A2058 cancer cell lines at a concentration of about 1 μM, control experiments clearly emphasizing the need for proteolytic activity. | |
| Cell line/ mice model | MCF-7 , KB, SK-MEL-28, GI-101A | |
| Additional information | NA | |
| PubChem ID | 74981710 | |
| Additional PMIDs | 22191568 33177555 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:12322-2 | |
| Safety | NA |