| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1068 | |
| Phytochemical name or plant extracts | Broccoli sprouts (BSp) | |
| PMID | 19197985 | |
| Literature evidence | Broccoli sprouts are a rich source of sulforaphane (SFN), an isothiocyanate that is metabolized via the mercapturic acid pathway and inhibits HDAC activity in human colon, prostate, and breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Sprout | |
| Source of phytochemicals or plant Extracts | Brassica oleracea | |
| Geographical availability | France, Great Britain, Spain | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Colon cancer, Prostate cancer | |
| Target gene or protein | DNMT1, HDAC1 | |
| Gene or Protein evidence | Our results indicate that green tea polyphenol EGCG and broccoli SFN can regulate both genetic and epigenetic mechanisms via, at least in part, directly inhibiting gene expression of two important epigenetic modulators, DNMT1 and HDAC1, leading to an opened chromatin structure and altered transcriptional factor binding status in the ERα promoter that may contribute to ERα transcriptional activation in ERα(−) breast cancer cells. | |
| Target pathways | ER signal pathway | |
| IC50 | NA | |
| Potency | Our studies indicate that combinatorial bioactive botanicals from GTPs and BSp are highly effective in inhibiting ERα-negative breast cancer due at least in part to epigenetic reactivation of ERα | |
| Cell line/ mice model | PC3, BPH-1, LnCaP, MCF-7 | |
| Additional information | SFN is an isothiocyanate, derived from glucoraphanin in broccoli and broccoli sprouts, that was first identified as a potent inducer of phase 2 detoxification enzymes [Zhang et al., 1992, Fahey et al., 1997]. | |
| PubChem ID | NA | |
| Additional PMIDs | 28839265 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:279435-1 | |
| Safety | NA |