| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-153 | |
| Phytochemical name or plant extracts | Britannin | |
| PMID | 25342596 | |
| Literature evidence | Annexin V/propidium iodide (PI) staining, Hoechst 33258 staining, and caspase-3/9 activity assay confirmed that britannin is able to induce apoptosis in MCF-7 and MDA-MB-468 cells. | |
| IUPAC name | [(3aS,5R,5aS,6S,8S,8aS,9S,9aR)-9-acetyloxy-8-hydroxy-5,8a-dimethyl-1-methylidene-2-oxo-4,5,5a,6,7,8,9,9a-octahydro-3aH-azuleno[6,5-b]furan-6-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Inula aucheriana | |
| Geographical availability | Iran, Transcaucasus, Turkey | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bax, p53 | |
| Gene or Protein evidence | The Western blot analysis showed that the expression of Bcl-2 was noticeably decreased in response to britannin treatment, while the expression of Bax protein was increased, which were positively correlated with elevated expression of p53. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Taken together, these results suggest that britannin inhibits growth of MCF-7 and MDA-MB-468 breast cancer cells through the activation of the mitochondrial apoptotic pathway and may potentially serve as an agent for breast cancer therapy. | |
| Cell line/ mice model | MCF-7, MDA-MB-468 | |
| Additional information | Moreover, britannin also increased reactive oxygen species (ROS) generation which in turn triggered the loss of mitochondrial transmembrane potential (ΔΨm) and the subsequent release of cytochrome c from mitochondria into cytosol. | |
| PubChem ID | 14466541 | |
| Additional PMIDs | 31603118 35775388 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:225761-1 | |
| Safety | NA |